Supersensitivity to prostaglandin in chronic neurogenic bladders

The bladder response to prostaglandin (PG test) was investigated in chronic neurogenic bladders by isometric cystometry and compared with the results obtained from normal subjects. The urinary bladder was filled with 100 ml of saline and 100 micrograms of prostaglandin 995 were injected intravenously. The changes in bladder and intra-abdominal pressures were observed for up to 20 min. A rise in detrusor pressure of more than 20 cm of water was judged a positive response. Out of 21 neurogenic bladders 12 had a positive response. The result of the PG test demonstrated a good correlation with the supersensitivity test to bethanechol chloride which was performed on these patients on a different day. All of the normal subjects had negative responses. It was concluded that the chronically denervated bladder is supersensitive to prostaglandin 995.