The non-surgical treatment of Peyronie's disease

Forty-five patients with Peyronie's disease are described. No patient received treatment for one year from the time of presentation. Three had a complete resolution of their symptoms and signs during this period. The remaining patients received injections of triamcinolone hexacetonide (Lederle) into the plaques at 6-weekly intervals for 36 weeks. Thirty-three per cent had complete or marked improvement in their symptoms; those responding were younger patients with small, firm, discrete plaques in the distal penis. We recommend a non-operative approach in this group. Surgery or chemotherapy should be reserved for those older patients with harder, larger or confluent plaques.