Fibrinogen in the 'hepato-renal syndrome': an experimental study

The pathogenesis of renal failure in jaundice is controversial. Several factors have been incriminated, including intravascular coagulation. We have investigated this hypothesis by by studying the deposition of radioactive fibrinogen in the kidney of jaundiced rats. Fibrinogen labelled with 125I was injected into rats whose bile duct was subsequently ligated. The radioactivity in the kidney was compared to that in blood and the renal uptake ratio calculated. This ratio (mean +/- s.e.mean) rose from 0.24 (+/- 0.04) to 2.93 (+/- 0.43) after ligation of the common bile duct. In contrast, in control rats who underwent a sham operation, the uptake ratio rose from 0.31 (+/- 0.03) to 0.96 (+/- 0.08). This deposition of 125I fibrinogen in the kidneys of jaundiced rats was significantly greater (P < 0.001) than that in control rats. The deposition was specific to the kidney compared with that in the heart, bowel, muscle and liver. In the control animal the uptake of 125I fibrinogen by the kidney was not different from that by other viscera.