Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary biliary cirrhosis: an epidemiological study

D R Triger

    British Medical Journal
    |September 20, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A study on primary biliary cirrhosis (PBC) found cases clustered around one water reservoir, suggesting an environmental cause. Water analysis was inconclusive, but further research is recommended.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Low-dose methotrexate is ineffective in primary biliary cirrhosis: long-term results of a placebo-controlled trial.

    Gastroenterology·1999
    Same author

    The natural history of chronic hepatitis C in haemophiliacs.

    British journal of haematology·1996
    Same author

    How valid are our reference standards of nutrition?

    Nutrition (Burbank, Los Angeles County, Calif.)·1995
    Same author

    Evaluation of nutritional status by using anthropometry in adults with alcoholic and nonalcoholic liver disease.

    The American journal of clinical nutrition·1994
    Same author

    Vagal dysfunction and impaired urinary sodium and water excretion in cirrhosis.

    The American journal of gastroenterology·1994
    Same author

    Autonomic and peripheral neuropathy in primary biliary cirrhosis.

    Journal of hepatology·1993
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Area of Science:

    • Hepatology
    • Epidemiology
    • Environmental Health

    Background:

    • Primary biliary cirrhosis (PBC) is a chronic liver disease of unknown etiology.
    • Understanding the environmental factors potentially contributing to PBC is crucial for public health.

    Purpose of the Study:

    • To investigate the geographical distribution and potential environmental triggers of primary biliary cirrhosis in Sheffield.
    • To explore the association between water supply and PBC prevalence.

    Main Methods:

    • A three-year epidemiological study (1977-1979) identified 34 cases of PBC in Sheffield.
    • Prevalence data was analyzed in relation to different water reservoirs serving the city.
    • Water quality analyses were conducted for reservoirs in high and low prevalence areas.

    Related Experiment Videos

    Main Results:

    • A point prevalence of 54 cases per million population was determined.
    • An apparent geographical clustering of PBC cases was observed.
    • Higher PBC prevalence was noted in areas supplied by one specific water reservoir compared to others, though water analyses revealed no significant differences.

    Conclusions:

    • Findings suggest a potential environmental agent may contribute to the development of primary biliary cirrhosis.
    • While water analysis was inconclusive, the geographical clustering warrants further epidemiological investigation.
    • Identifying environmental risk factors is essential for understanding and potentially preventing PBC.