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Extranodal non-Hodgkin's lymphoma

S Reddy, E Pellettiere, V Saxena

    Cancer
    |November 1, 1980
    PubMed
    Summary

    Radiotherapy effectively treated Stage I and II extranodal non-Hodgkin's lymphoma. Survival rates were 74% for Stage I and 38% for Stage II patients, with diffuse histology being most common.

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    Area of Science:

    • Oncology
    • Radiotherapy
    • Hematology

    Background:

    • Extranodal non-Hodgkin's lymphoma (NHL) presents unique treatment challenges.
    • Radiotherapy has been a cornerstone in managing localized NHL.
    • Understanding outcomes based on stage and histology is crucial for treatment planning.

    Purpose of the Study:

    • To evaluate the long-term outcomes of radiotherapy for Stages I and II extranodal NHL.
    • To analyze survival rates based on disease stage, histologic type, and site of origin.
    • To identify patterns of recurrence in patients treated with curative intent.

    Main Methods:

    • Retrospective analysis of 42 patients with Stages I and II extranodal NHL treated between 1964-1977.
    • Pathologic specimens reclassified using Rappaport et al. criteria.
    • Curative intent radiotherapy administered at Rush-Presbyterian-St. Luke's Medical Center.

    Main Results:

    • Diffuse histology was observed in 80% of patients.
    • Five-year actuarial survival rates were 74% for Stage I and 38% for Stage II.
    • Head and neck (19 patients) and gastrointestinal tract (15 patients) were the most common extranodal sites.

    Conclusions:

    • Radiotherapy offers a viable curative option for select patients with early-stage extranodal NHL.
    • Outcomes vary significantly by stage, highlighting the importance of accurate staging.
    • Further research into optimal radiotherapy techniques and patterns of recurrence is warranted.

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