Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective tumor heating by shortwave radiofrequency (RF)

S P Auda, H R Steinert, E G Elias

    Cancer
    |November 1, 1980
    PubMed
    Summary

    High frequency dielectric heating showed selective temperature increases in larger experimental tumors ( > 1.0 cu cm) compared to surrounding tissues in rats. Systemic temperatures remained stable, with no tumor regression observed at this dosage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Melanoma vaccines, revisited: a review, update.

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2014
    Same author

    Radiation-induced enterocolitis: basic and applied science.

    The European journal of surgery. Supplement. : = Acta chirurgica. Supplement·1999
    Same author

    Adjuvant immunotherapy in melanoma with irradiated autologous tumor cells and low dose cyclophosphamide.

    Journal of surgical oncology·1997
    Same author

    The needle biopsy should replace open excisional biopsy.

    Annals of surgical oncology·1996
    Same author

    Clear and present danger: a medical-legal dilemma.

    Maryland medical journal (Baltimore, Md. : 1985)·1996
    Same author

    Surgical transfer of the sartorius muscle to the groin after lymphadenectomy or debridement: CT findings.

    AJR. American journal of roentgenology·1996

    Area of Science:

    • Oncology
    • Biophysics
    • Medical Physics

    Background:

    • External high-frequency dielectric heating is a method for thermal therapy.
    • Understanding thermal selectivity is crucial for optimizing hyperthermia treatments.
    • Previous studies have explored dielectric heating for tumor treatment.

    Purpose of the Study:

    • To investigate the thermal selectivity of high-frequency dielectric heating in experimental solid tumors.
    • To compare tumor temperature gradients with those of surrounding subcutaneous tissue, muscle, and systemic temperature.
    • To assess the effect of tumor size on thermal selectivity.

    Main Methods:

    • Experimental solid tumors (methylcholantrene-induced sarcoma) were established in Fischer rats.
    • Local dielectric heating at 13.56 MHz was applied for 1 hour to tumor-bearing areas.

    Related Experiment Videos

  • Temperature was measured in tumor, subcutaneous tissue, muscle, and rectum using thermocouple probes and a mercury thermometer.

    • Main Results:

    • A significant selective temperature gradient was observed in tumor masses greater than 1.0 cu cm compared to subcutaneous and muscle tissues.
    • No thermal selectivity was detected in smaller tumors or in non-tumor-bearing control animals.
    • Systemic temperatures did not increase, and no tumor regression was observed at the applied dosage. Burns occurred when normal tissue exceeded 43°C.

    Conclusions:

    • High-frequency dielectric heating can achieve selective hyperthermia in larger experimental tumors.
    • Tumor size is a critical factor influencing thermal selectivity.
    • Further research is needed to optimize dosage for therapeutic effects and minimize normal tissue damage.