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Related Experiment Videos

Acute cadmium intoxication in inbred mice: a study on strain differences

A Hata, H Tsunoo, H Nakajima

    Chemico-Biological Interactions
    |October 1, 1980
    PubMed
    Summary

    Cadmium chloride (CdCl2) injection caused significant mortality and liver damage in C3H mice, unlike DBA/2 mice. This strain-dependent toxicity correlated with lower metallothionein (MT) induction in C3H mice.

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    Area of Science:

    • Toxicology
    • Comparative Pathology
    • Biochemistry

    Background:

    • Cadmium (Cd) is a toxic heavy metal with significant environmental and health implications.
    • Strain-specific differences in susceptibility to toxic agents are well-documented in animal models.
    • Metallothionein (MT) is a key protein involved in heavy metal detoxification.

    Purpose of the Study:

    • To investigate the strain-dependent toxicity of cadmium chloride (CdCl2) in mice.
    • To compare the pathological effects of CdCl2 across different mouse strains.
    • To explore the relationship between MT induction and CdCl2-induced toxicity.

    Main Methods:

    • Male C3H, BALB/c, and DBA/2 mice were administered a single subcutaneous dose of CdCl2 (30 mumol/kg).
    • Survival rates were monitored over 48 hours.

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  • Liver histology was performed at 6 and 48 hours post-injection to assess pathological changes.
  • Metallothionein (MT) induction levels were quantified at 6 hours post-injection.

    • Main Results:

    • C3H mice exhibited high mortality within 15 hours, while DBA/2 mice showed 100% survival at 48 hours.
    • Histological examination revealed severe liver hemorrhage, fatty change, zonal necrosis, and congestion in C3H mice.
    • These pathological findings were significantly less pronounced in BALB/c and DBA/2 mice.
    • MT induction at 6 hours was markedly lower in C3H mice compared to the other strains.

    Conclusions:

    • Mouse strain significantly influences susceptibility to acute cadmium toxicity.
    • C3H mice are highly vulnerable to CdCl2-induced hepatotoxicity, characterized by severe pathological changes.
    • Reduced metallothionein induction in C3H mice may contribute to their increased sensitivity to cadmium toxicity.