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Transient liver hypoxia after liver hilus dearterialization
Annales Chirurgiae Et Gynaecologiae
|January 1, 1978
Summary
Liver dearterialization causes temporary hypoxia, indicated by decreased oxygen and increased carbon dioxide levels. Postoperative 60% oxygen breathing effectively prevents these changes in liver tissue gas tensions.
Area of Science:
- Hepatobiliary Surgery
- Surgical Physiology
- Organ Perfusion
Background:
- Liver dearterialization can induce ischemic changes.
- Previous studies lacked real-time liver tissue gas tension measurements post-operation.
Purpose of the Study:
- To measure liver tissue gas tensions after dearterialization.
- To assess the impact of cholecystectomy and oxygen therapy on these changes.
Main Methods:
- 15 dogs underwent liver dearterialization (with or without cholecystectomy); 6 controls had sham operations.
- Liver tissue oxygen (pO2) and carbon dioxide (pCO2) tensions were measured using Silastic tonometers.
- Measurements were taken intraoperatively and on postoperative days 1 and 7.
Main Results:
- Dearterialization caused a significant transient decrease in liver pO2 and increase in pCO2 within 20 minutes.
- These gas tension abnormalities resolved by postoperative day 1.
- Breathing 60% oxygen postoperatively prevented these gas tension changes.
Conclusions:
- Liver dearterialization induces a short-term hypoxic state.
- Postoperative hyperoxia (60% oxygen) effectively mitigates this transient hypoxia.
- Cholecystectomy did not significantly alter the observed gas tension changes.