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STS 557 as an interceptive in rodents and baboons

M Oettel, A Komor, N P Goncharov

    Contraception
    |May 1, 1980
    PubMed
    Summary
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    The new progestin STS 557 shows promise as an interceptive agent, effectively reducing implantations in rodents. In baboons, a low dose of STS 557 significantly prevented pregnancy when given post-coitally.

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology
    • Contraception

    Background:

    • Progestins are crucial components of oral contraceptives.
    • New progestins are continuously being developed for improved contraceptive efficacy and safety.
    • Understanding the interceptive mechanisms of progestins is vital for developing novel family planning methods.

    Purpose of the Study:

    • To evaluate the interceptive action of the novel progestin STS 557.
    • To compare the efficacy of STS 557 with existing progestins used in oral contraceptives.
    • To assess the potential of STS 557 as a post-coital contraceptive agent.

    Main Methods:

    • Animal studies were conducted using mice, rats, guinea pigs, and baboons.
    • Deciduoma formation and implantation rates were assessed in rodents.

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  • Post-coital administration of STS 557 was tested in guinea pigs and baboons.
  • Pregnancy rates were compared between STS 557 treated groups and controls.

    • Main Results:

    • STS 557, norethindrone, and norethindrone acetate reduced deciduoma formation and implantation in mice and rats.
    • Chlormadinone acetate and levonorgestrel were less effective in preventing early pregnancy in the tested models.
    • STS 557 demonstrated significant contraceptive efficacy in baboons when administered 3 or 6 hours post-mating, with only one pregnancy in 60 cycles.
    • STS 557 was ineffective as a post-coital agent in guinea pigs.

    Conclusions:

    • STS 557 exhibits potent interceptive properties, particularly effective in preventing implantation in rodents.
    • The progestin STS 557 shows significant potential as a post-coital contraceptive agent in primates.
    • Further research into STS 557 could lead to the development of a new interceptive method for family planning.