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Updated: Jul 30, 2026

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Levels of cefuroxime in bronchial secretion
Abstract:
Levels of cefuroxime in bronchial secretion were measured in 49 patients requiring bronchoscopy for diagnostic purposes. Patients were randomly allocated to one of 4 groups which differed with respect to the size (750 mg or 1.5 g) and number (1 or 7) of intravenous doses of cefuroxime given approximately 1 hour prior to sampling. Levels of cefuroxime achieved after administration of all 4 dosages were sufficient to exceed the MIC values for the major chest pathogens. Penetration of cefuroxime into bronchial secretion was also found to be dose-related.
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