Oesophageal ulceration due to emepronium bromide

Area of Science:

• Gastroenterology
• Pharmacology

Background:

• Urinary anti-spasmodic agents are commonly prescribed.
• Emepronium bromide is used to treat urinary incontinence and spasms.

Observation:

• Four patients developed severe retrosternal pain exacerbated by swallowing.
• Endoscopic examination revealed mid-esophageal ulceration in all cases.

Findings:

• Esophageal damage, including ulceration, was directly linked to emepronium bromide ingestion.
• Discontinuation of emepronium bromide led to rapid symptom resolution.

Implications:

• Emepronium bromide poses a risk of esophageal injury.
• Clinicians should be aware of this potential adverse effect when prescribing the drug.