[Immunopathological aspects of nucleolar activation. 1. Changes of nucleolar activation during the course of primary...

During the primary immune response induced by the administration of sheep erythrocytes in mice, nucleolar activation was observed in macrophages, lymphocytes as well as in plasmacytes. The first maximum (4.6%) was observed on day 3 in macrophagic cells. Maximal activation of plasmoblasts (6.6%) and plasmacytes (5.9%) was observed on day the lymphoid series the first maximum in the occurrence of cells showing specific immunological activatin was as follows: large lymphocytes on day (6.5%), medium-sized lymphocytes on day 7 (6.6%) and, ultimately, small lymphocytes (6.3%) on day 8. The study verified the possibility of using nucleolar staining for estimating its functional morphology and thus following the changes of specific immunological activation during the primary immunological response.