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Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
793
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

660
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
660
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

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Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
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Related Experiment Video

Updated: Apr 12, 2026

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
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Zinc absorption in Crohn's disease

G C Sturniolo, M M Molokhia, R Shields

    Gut
    |May 1, 1980
    PubMed
    Summary

    Patients with Crohn's disease exhibit lower serum zinc levels, but this may reflect low albumin. Zinc absorption is significantly impaired in Crohn's disease patients, potentially causing zinc deficiency.

    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Clinical Medicine

    Background:

    • Crohn's disease (CD) is associated with potential complications, including nutritional deficiencies.
    • Zinc deficiency is a recognized concern in patients with inflammatory bowel diseases like CD.
    • The underlying causes of zinc deficiency in CD require further investigation.

    Purpose of the Study:

    • To investigate serum zinc levels in patients with Crohn's disease.
    • To assess zinc absorption in Crohn's disease patients.
    • To determine if malabsorption contributes to zinc deficiency in Crohn's disease.

    Main Methods:

    • Serum zinc concentrations were measured in 33 Crohn's disease patients and 58 healthy controls.
    • Zinc absorption was evaluated in 7 Crohn's disease patients using a novel technique with a short-lived zinc isotope (69mZn).

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  • Plasma appearance and disappearance curves were analyzed using a deconvolution computer program to quantify zinc absorption.

    • Main Results:

    • Serum zinc concentrations were significantly lower in Crohn's disease patients (9.18 ± 2.3 μmol) compared to controls (13.6 ± 1.73 μmol; P < 0.0005).
    • Low serum zinc correlated with low serum albumin, questioning its utility as a sole indicator of zinc deficiency.
    • Zinc absorption was considerably impaired in Crohn's disease patients (9–45%) compared to normal subjects (38–75%).

    Conclusions:

    • While serum zinc is lower in Crohn's disease, it may not accurately reflect zinc status due to albumin correlation.
    • Impaired zinc absorption is a significant finding in Crohn's disease patients.
    • This malabsorption of zinc is a likely contributor to zinc deficiency in the context of Crohn's disease.