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Related Experiment Video

Updated: Jun 18, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

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Weight loss in primary biliary cirrhosis

G J Beckett, N Dewhurst, N D Finlayson

|September 1, 1980

Summary

In primary biliary cirrhosis patients, low duodenal bile salt levels did not correlate with high fecal fat. Weight loss in this condition may stem from malabsorption factors beyond reduced bile salts.

Area of Science:

Gastroenterology
Hepatology
Digestive Physiology

Background:

Primary biliary cirrhosis (PBC) is a chronic liver disease.
Weight loss is a common symptom in PBC patients.
Malabsorption can contribute to weight loss in various conditions.

Purpose of the Study:

To investigate the relationship between duodenal bile salt concentrations and malabsorption in patients with primary biliary cirrhosis.
To explore potential causes of weight loss in PBC.

Main Methods:

Duodenal bile salt concentrations were measured over a 24-hour period in six PBC patients on a standard diet.
Fecal fat excretion and xylose absorption tests were performed.
Small bowel radiology and jejunal biopsies were assessed.

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Determining Bile Duct Density in the Mouse Liver

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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

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Determining Bile Duct Density in the Mouse Liver

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

Main Results:

No direct correlation was observed between elevated fecal fat excretion and reduced duodenal bile salt concentrations.
Xylose absorption was impaired in five out of the six patients.
Patients exhibited normal small bowel radiography and jejunal histology.

Conclusions:

Reduced small intestinal bile salt concentration is unlikely to be the primary driver of malabsorption and subsequent weight loss in primary biliary cirrhosis.
Other factors contributing to malabsorption should be investigated in PBC patients experiencing weight loss.