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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
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Related Experiment Video

Updated: Jul 12, 2026

Vessel-sparing Excision and Primary Anastomosis
08:09

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Published on: January 7, 2019

Obstructive uropathy after pan-proctocolectomy for ulcerative colitis

M C Wilson, A R Berry, T J McNair

    Gut
    |September 1, 1980
    PubMed
    Summary

    Pan-proctocolectomy for ulcerative colitis can lead to obstructive uropathy mimicking retroperitoneal fibrosis. This rare complication, occurring in about 10% of patients, requires consideration in post-operative care.

    Area of Science:

    • Gastroenterology
    • Urology
    • Surgical Complications

    Background:

    • Ulcerative colitis is a chronic inflammatory bowel disease.
    • Pan-proctocolectomy is a surgical procedure involving the removal of the entire colon and rectum.
    • Postoperative complications require careful monitoring and diagnosis.

    Observation:

    • Two patients who underwent pan-proctocolectomy for ulcerative colitis developed obstructive uropathy.
    • The uropathy presented with clinical and radiological features consistent with retroperitoneal fibrosis.
    • This complication was observed some time after the surgical procedure.

    Findings:

    • The incidence of obstructive uropathy post-pan-proctocolectomy for ulcerative colitis is estimated to be around 10%.
    • Retroperitoneal fibrosis is a potential, albeit uncommon, sequela of this surgery.

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  • Non-specific symptoms in patients following this surgery may indicate this complication.
  • Implications:

    • Clinicians should consider obstructive uropathy with retroperitoneal fibrosis in patients with non-specific symptoms after pan-proctocolectomy for ulcerative colitis.
    • Early diagnosis and management are crucial for favorable patient outcomes.
    • Further research may elucidate the exact mechanism linking this surgery to retroperitoneal fibrosis.