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Related Experiment Videos

Sperm antibody testing in infertile men

C Schoenfeld, R D Amelar, L Dubin

    Archives of Andrology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Male infertility may be linked to sperm autoantibodies. The Kibrick and Isojima tests detected these antibodies in 20% and 6% of men, respectively, highlighting their importance in diagnosing unexplained infertility.

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    Area of Science:

    • Reproductive Immunology
    • Andrology
    • Infertility Diagnostics

    Background:

    • Sperm autoantibodies can impact male fertility.
    • Prevalence and diagnostic significance in normospermic males require further investigation.

    Purpose of the Study:

    • To assess the incidence of circulating sperm autoantibodies in males.
    • To evaluate the utility of sperm-agglutination and sperm-immobilizing tests in diagnosing male infertility.

    Main Methods:

    • Kibrick sperm-agglutination test used on 600 males.
    • Isojima sperm-immobilizing test used on 300 males.
    • Analysis of antibody titers in normospermic and infertile men.

    Main Results:

    • 20% of 600 males showed circulating sperm-agglutinating antibodies.

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  • 41% of 80 normospermic males with semen agglutination had positive Kibrick test titers.
  • 6% of 300 males exhibited sperm-immobilizing antibodies via the Isojima test.

    • Conclusions:

    • Sperm autoantibodies are prevalent in males, including those appearing normospermic.
    • Sperm-agglutination and sperm-immobilizing tests are crucial for diagnosing unexplained male infertility.