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Related Experiment Videos

Early changes in the structure of rat sciatic nerves by ligation

I Nagatsu, N Karasawa, N Shimizu

    Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku
    |November 1, 1978
    PubMed
    Summary

    Sciatic nerve ligation causes early morphological changes in larger myelinated and non-myelinated nerve fibers. These changes, particularly in proximal segments, suggest axoplasm accumulation of catecholamine synthesizing enzymes.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Histology

    Background:

    • Nerve injury, such as sciatic nerve ligation, can lead to complex cellular responses.
    • Understanding the spatiotemporal dynamics of enzyme accumulation post-injury is crucial for nerve regeneration research.

    Purpose of the Study:

    • To investigate morphological alterations in rat sciatic nerve segments following ligation.
    • To identify changes related to the accumulation of catecholamine synthesizing enzymes.

    Main Methods:

    • Light and electron microscopy were employed.
    • Analysis of nerve segments proximal and distal to the ligature over a 4-day period.

    Main Results:

    • Earliest changes observed in larger myelinated nerve fibers (0.5-1.0 mm segments).

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  • Non-myelinated fibers showed axonal enlargement, increased matrix density, microtubules, vesicles, and vacuoles.
  • Changes were more pronounced in proximal segments, indicating potential axoplasm accumulation.

    • Conclusions:

    • Nerve ligation induces distinct morphological changes in different nerve fiber types.
    • Axoplasm accumulation in non-myelinated fibers may be linked to enzyme buildup proximal to the ligation site.