Surface membrane enzyme, chemotactic peptide binding activities, and chemotactic responsiveness of rabbit peripheral...

The chymotrypsin-like esterase activity of plasma membrane and the ecto-5'nucleotidase and ecto-p-nitrophenyl phosphatase activities in peritoneal neutrophils are 2- and 3-fold higher than peripheral blood neutrophils. The binding of the chemotactic peptide, formyl norleucyl-leucyl-phenyl-alanine to peritoneal neutrophils is 6- to 7-fold higher than to peripheral blood neutrophils. The chemotactic responsiveness of peritoneal neutrophils to the chemotactic peptide is 5-fold greater than peripheral blood neutrophils. However, there was no significant difference in the chemotactic responsiveness to complement component C5a between the blood and peritoneal cells.