Furosemide reduces gastric acid secretion

Furosemide (10(-3) M) reduced acid secretion of isolated fundic mucosa of the guinea pig by 40%, and lowered the short circuit current, carried mainly by Cl- ions, by 49 +/- 2 (SE) %. These effects occurred within seconds of application of the drug to the serosal side of the mucosa and were fully reversible. When the drug was applied to the mucosal side, the same effects were obtained.