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Furosemide reduces gastric acid secretion
Israel Journal of Medical Sciences
|September 1, 1980
Summary
The diuretic furosemide significantly inhibits gastric acid secretion and chloride ion transport in guinea pig stomachs. These rapid, reversible effects occur regardless of whether the drug is applied to the mucosal or serosal side.
Area of Science:
- Gastroenterology
- Pharmacology
- Physiology
Background:
- Gastric acid secretion is a critical physiological process regulated by various factors.
- Understanding the mechanisms of acid secretion is vital for treating acid-related disorders.
- Diuretics can potentially influence gastrointestinal functions.
Purpose of the Study:
- To investigate the effect of furosemide on gastric acid secretion.
- To determine the impact of furosemide on ion transport in the gastric mucosa.
- To explore the site of action for furosemide's effects on gastric function.
Main Methods:
- Isolated guinea pig fundic mucosa was used for experiments.
- Acid secretion was measured.
- Short-circuit current, reflecting ion transport, was monitored.
- Furosemide was applied to both mucosal and serosal sides.
Main Results:
- Furosemide (10(-3) M) reduced acid secretion by 40%.
- Short-circuit current, primarily carried by chloride ions, decreased by 49%.
- These effects were rapid, reversible, and independent of the application side.
Conclusions:
- Furosemide inhibits gastric acid secretion and chloride transport in the gastric mucosa.
- The drug's action is not dependent on the direction of application, suggesting a direct effect on the tissue.
- Furosemide may have implications for conditions involving gastric acid hypersecretion.