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High flux hemofiltration

J P Bosch, R Geronemus, S Glabman

    Artificial Organs
    |November 1, 1978
    PubMed
    Summary
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    A new hollow fiber hemofilter achieves high ultrafiltration rates in post-dilution hemofiltration. This method offers urea clearances comparable to hemodialysis without adverse effects, even at high filtration fractions.

    Area of Science:

    • Nephrology
    • Biomedical Engineering
    • Renal Replacement Therapy

    Background:

    • Post-dilution hemofiltration is a renal replacement therapy.
    • New hemofilters are continuously developed to improve efficiency and safety.
    • Assessing performance metrics like ultrafiltration rate and solute clearance is crucial.

    Purpose of the Study:

    • To evaluate the performance of a novel hollow fiber hemofilter.
    • To measure ultrafiltration rates and urea clearances during post-dilution hemofiltration.
    • To assess the safety and efficacy of high filtration fractions.

    Main Methods:

    • Experiments utilized a new hollow fiber hemofilter.
    • Ultrafiltration rates were measured.
    • Whole blood urea clearances were determined in post-dilution hemofiltration.

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    Main Results:

    • The new hemofilter achieved high ultrafiltration rates.
    • High filtration fractions (above 45%) were tolerated without adverse effects.
    • Small solute clearances comparable to hemodialysis were observed.

    Conclusions:

    • The novel hemofilter is effective for post-dilution hemofiltration.
    • High ultrafiltration rates and clearances can be achieved safely.
    • This technology shows promise for efficient renal replacement therapy.