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Related Experiment Videos

Methadone-disulfiram interaction during methadone maintenance

T G Tong, N L Benowitz, M J Kreek

    Journal of Clinical Pharmacology
    |August 1, 1980
    PubMed
    Summary

    Disulfiram does not significantly interact with methadone for alcoholism treatment. This study found no evidence of disulfiram inhibiting methadone metabolism or affecting opiate withdrawal symptoms.

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    Area of Science:

    • Pharmacology
    • Clinical Toxicology
    • Addiction Medicine

    Background:

    • Methadone is a key medication for opioid use disorder treatment.
    • Disulfiram is used to deter alcohol consumption.
    • Potential drug interactions between methadone and disulfiram require investigation.

    Purpose of the Study:

    • To investigate the pharmacokinetic and pharmacodynamic interaction between methadone and disulfiram.
    • To determine if disulfiram affects methadone metabolism or clinical effects.

    Main Methods:

    • Seven subjects on methadone maintenance received 500 mg/day disulfiram for seven days.
    • Plasma methadone levels, urinary metabolite excretion, and subjective opiate symptoms were monitored.
    • Measurements were taken before, during, and after disulfiram administration.

    Main Results:

    • Mean trough plasma methadone concentrations and half-lives were lower/shorter during disulfiram treatment (not statistically significant).
    • The ratio of urinary methadone to its pyrrolidine metabolite decreased, suggesting enhanced N-demethylation.
    • Disulfiram did not alter opiate intoxication or abstinence symptoms.

    Conclusions:

    • Disulfiram may alter methadone disposition, potentially increasing N-demethylation.
    • No significant drug interaction was observed between disulfiram and methadone at the doses studied.
    • Disulfiram is unlikely to interfere with methadone maintenance therapy for alcoholism management.

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