[The ocular toxicity of cephaloridine - A clinical and experimental study (author's transl)]

Cephaloridine is an antibiotic well known for its remarkable efficacy and absence of ocular toxicity. However four cases have been reported with severe ocular affect; a unilateral retinitis pigmentosa with extinction of the E.R.G. and total irreversible blindness has been noted in three cases after sub-conjunctival or intra-camerular injection of cephaloridine, one case showed a slight improvement. In an experimental study undertaken on rabbits no ocular toxicity has been noted during sub-conjunctival or intra-camerular injection whilst very low doses of intravitreous injection reproduce exactly the same facts as observed in man. These various studies give proof of the ocular toxicity of cephaloridine and involves particular caution in its utilizaiton for endo-ocular diseases.