Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plutonium in [99mTc] Pertechnetate for clinical use: concise communication

L Johansson, S Mattsson

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |November 1, 1980
    PubMed
    Summary

    Alpha-emitting plutonium (Pu-239 + 240) was detected in technetium-99m (Tc-99m) generators. This contamination, originating from uranium impurities in molybdenum, necessitates stricter controls in radiopharmaceutical production.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of Current and Previous Smoking on Fracture Risk in Older Women: The Role of Physical Function, Bone Density and Bone Microarchitecture.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
    Same author

    Effect of FRAXplus adjustments on fracture risk reclassification in older Swedish women-results from the SUPERB-study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
    Same author

    Factors influencing time to support in young-onset dementia: survival analysis of data from the Swedish Dementia Registry (SveDem).

    Aging & mental health·2025
    Same author

    A proteomics perspective on 2 years of high-intensity training in horses: a pilot study.

    Scientific reports·2024
    Same author

    A metabolomics perspective on 2 years of high-intensity training in horses.

    Scientific reports·2024
    Same author

    Mechanical loading intensities affect the release of extracellular vesicles from mouse bone marrow-derived hematopoietic progenitor cells and change their osteoclast-modulating effect.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2023

    Area of Science:

    • Nuclear Chemistry
    • Radiopharmaceutical Quality Control
    • Medical Isotope Production

    Background:

    • Technetium-99m (Tc-99m) is a widely used medical radioisotope.
    • Tc-99m is typically eluted from molybdenum-99 (Mo-99) generators.
    • Ensuring the radiochemical purity of Tc-99m eluates is critical for patient safety.

    Purpose of the Study:

    • To investigate the presence of alpha-emitting radionuclides in Tc-99m pertechnetate.
    • To identify the source and extent of any detected contamination.
    • To provide recommendations for improving radiopharmaceutical quality.

    Main Methods:

    • Analysis of pertechnetate from 31 different Tc-99m generators.
    • Quantification of alpha-emitting radionuclides, specifically plutonium (Pu-239 + 240).

    Related Experiment Videos

  • Determination of activity ratios, including Pu-239+240/Tc-99m and Pu-241/Pu-239+240.

    • Main Results:

    • Significant levels of plutonium (Pu-239 + 240) were found in Tc-99m eluates from one manufacturer's generators.
    • The Pu-239+240/Tc-99m activity ratio ranged from 1.3 x 10(-12) to 1.4 x 10(-11).
    • Americium-241 (Am-241), a decay product of Pu-241, was also detected, with an estimated Pu-241/Pu-239+240 ratio of 8:1.

    Conclusions:

    • Plutonium contamination in Tc-99m generators likely originates from uranium impurities in neutron-activated molybdenum.
    • Recommendations include setting upper limits for plutonium in eluates and restricting uranium content in Mo-99 production.
    • Stricter quality control measures are needed for Mo-99 production to ensure radiopharmaceutical safety.