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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Biologic gastric emptying time in diabetic patients, using Tc-99m-labeled resin-oatmeal with and without
Abstract:
Biologic gastric emptying time (BGET) was measured in 24 patients with severe diabetes mellitus complicated by vascular damage and peripheral or sensory neuropathy. This population had a BGET of 192 +/- 32.9 min (mean +/- s.e.m. normal 40-85 min). Patients with diabetic gastroenteropathy had prolongation of BGET to 295 +/- 45 (p < 0.05). Metoclopramide significantly shortened BGET in this subgroup to 101 +/- 40 min, with return to normal values in eight of the 12 patients given the drug. The Tc-99m-labeled resin-oatmeal test meal used as described in this study provides a reliable measure of BGET and of the response to metoclopramide.
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