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Delayed pseudopregnancy in the mouse

S R Milligan, A A Khan, B C Thorne

    Journal of Reproduction and Fertility
    |September 1, 1980
    PubMed
    Summary
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    Bromocriptine treatment in pregnant mice caused them to return to oestrus, leading to more pseudopregnancies. This suggests a memory component in the mouse luteotrophic system, impacting reproductive cycles.

    Area of Science:

    • Reproductive biology
    • Endocrinology
    • Mammalian reproduction

    Background:

    • The luteotrophic system is crucial for maintaining pregnancy in mammals.
    • Understanding factors that influence reproductive cyclicity is key to reproductive biology.

    Purpose of the Study:

    • To investigate the effect of bromocriptine on the reproductive cycles of pregnant mice.
    • To explore the potential 'mnemonic' component of the luteotrophic system.

    Main Methods:

    • Female mice were treated with bromocriptine on day 1 or 3 of pregnancy.
    • Reproductive cycles and pseudopregnancy incidence were monitored.
    • Data were compared to unmated control groups.

    Main Results:

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  • Bromocriptine administration induced a return to oestrus in a significant number of pregnant mice.
  • The incidence of extended cycles (7-10 days) and pseudopregnancies was notably higher in treated mice compared to controls.
  • These findings indicate a disruption of the normal luteotrophic support.

    • Conclusions:

    • Bromocriptine treatment disrupts pregnancy maintenance in mice by affecting the luteotrophic system.
    • The results support the hypothesis of a 'mnemonic' or memory-like component within the mouse luteotrophic system.
    • This suggests that early pregnancy signals can have lasting effects on reproductive cyclicity.