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Feminizing adrenocortical carcinoma in man
The Japanese Journal of Surgery
|June 1, 1980
Summary
Adrenocortical tumors can cause significant hormonal imbalances, leading to symptoms like gynecomastia. Surgical removal of the tumor effectively resolved these endocrine-related issues in this patient.
Area of Science:
- Endocrinology
- Oncology
- Urology
Background:
- Adrenocortical tumors are rare neoplasms originating from the adrenal cortex.
- These tumors can exhibit hormone-secreting properties, leading to various clinical manifestations.
- Gynecomastia and impotence in adult males can be indicative of underlying endocrine dysfunction.
Observation:
- A 37-year-old male presented with marked gynecomastia and impotence.
- Biochemical evaluation revealed elevated urinary 17-ketosteroids (17-KS), 17-hydroxycorticosteroids (17-OHCS), and serum estrogen levels.
- Imaging confirmed the presence of a large adrenocortical tumor weighing 800g.
Findings:
- Surgical en bloc resection of the 800g adrenocortical tumor was successfully performed.
- Postoperatively, the patient's gynecomastia resolved completely.
- The patient reported restoration of libido and showed no signs of recurrence one year after surgery.
Implications:
- This case highlights the importance of considering endocrine-active adrenocortical tumors in the differential diagnosis of gynecomastia and impotence.
- Complete surgical excision is an effective treatment for hormone-secreting adrenocortical tumors, leading to resolution of clinical symptoms.
- Long-term surveillance is crucial to monitor for tumor recurrence after surgical management.