The effect of diet on some parameters measured in toxicological studies in the rat

The bodyweight, food consumption and various biochemical and haematological parameters were measured in, and breeding and histological studies made of, groups of rats fed 6 different diets. All diets acceptably supported reproduction. 1 diet restricted bodyweight gain by 30% and increased plasma alanine transaminase activity. Nephrocalcinosis was seen in females fed diets with a calcium:phosphorous ratio of < 1. Levels of dietary protein were positively correlated with the incidence of renal pelvic dilatation in offspring at 7 weeks of age.