Pathology of the clitoral and prepucial glands in aging F344 rats

Clitoral and prepucial glands from 112-week-old untreated F344 male and female rats were studied histologically. Lesions included acinar cell atrophy, fibrosis, duct distension, inflammation, and neoplasms. Acinar cell atrophy and fibrosis were seen in 68% of the males and 58% of the females. More severe acinar cell atrophy, fibrosis, and inflammation were seen in the male rats. The neoplasms were small and circumscribed, cystic, or papillary cystic adenomas derived from acinar cells. One cystic adenocarcinoma was diagnosed.