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Updated: Aug 19, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
[Blood serum lipids and lipoproteins in rabbits chronically exposed to CS2]
Abstract:
In rabbits chronically intoxicated with CS2, the lipids and lipoproteins concentration in the blood serum and cholesterol content in the serum lipoproteins and arterial wall were evaluated. It has been shown, that 6 months' exposure to CS2 at the concentration of 0,5-0,6 mg/l resulted in: (1) an increase in total and free cholesterol, cholesterol esters, triglycerides and phospholipides content in serum; (2) a relative increase in serum VLDL and LDL content and decrease in HDL fraction content; (3) a significant increased in cholesterol concentration in LDL and a slight one in VLDL and LDL fractions. No changes in the concentration of lipids in the aorta wall of CS2-intoxicated animals were observed.

