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Updated: Aug 13, 2026

In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection
Published on: November 27, 2014
Abstract:
The materno-fetal relationship is governed by critical levels of progesterone (P) and prostaglandin F2 alpha (PGF2 alpha). The 'see-saw' in concentration of these molecules maintain and terminate pregnancy in placental mammals. Apart from the enhancement or suppression of uterine contractility by PGF2 alpha and P respectively, the hypothesis in these pages is that the initiating event of parturition is a maternal immunologic repudiation of the feto-placental unit. This immunoregulative theory of parturition is not in contradiction to other physico-endocrinologic theories of labour; but is here presented to further explain some, heretofore, puzzling empirical data witnessed in complications of pregnancy and induced abortion, when Pgs are employed as abortifacients.
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