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Supglottic coccidioidomycosis presenting with persistent stridor

S Gardner, D Seilheimer, F Catlin

    Pediatrics
    |October 1, 1980
    PubMed
    Summary
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    Localized subglottic coccidioidomycosis, a rare fungal infection, was successfully treated in a young child. Intravenous amphotericin B eradicated the laryngeal lesion, offering a new treatment approach for this uncommon condition.

    Area of Science:

    • Mycology
    • Pediatric Infectious Diseases
    • Otolaryngology

    Background:

    • Coccidioidomycosis, a fungal infection, typically presents with disseminated disease.
    • Localized laryngeal coccidioidomycosis is exceptionally rare in medical literature.
    • Subglottic involvement in pediatric fungal infections poses unique diagnostic and management challenges.

    Observation:

    • A 13-month-old boy presented with persistent stridor, a high-pitched breathing sound.
    • Clinical examination and subsequent investigations revealed localized subglottic coccidioidomycosis.
    • The patient had no signs or symptoms suggestive of disseminated fungal infection.

    Findings:

    • Intravenous administration of amphotericin B was initiated for medical management.

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  • The subglottic fungal lesion showed a complete response to the antifungal therapy.
  • No recurrence or adverse effects were noted following treatment.

    • Implications:

    • This case highlights the possibility of localized subglottic coccidioidomycosis in children.
    • Effective medical management with amphotericin B can lead to complete eradication of the disease.
    • Early diagnosis and prompt treatment are crucial for favorable outcomes in pediatric fungal airway infections.