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[Diagnostic and prognostic values of vacuolated polymorphonuclear neutrophils (author's transl)]
La Nouvelle Presse Medicale
|September 27, 1980
Abstract:
The presence of vacuolated polymorphonuclear neutrophils in blood smears of patients suffering from infection appears to be associated with massive bacterial growth and to constitute a very early symptom of rapidly life-threatening septicaemia. When these cells persist for more than 36 hours, the disease may be considered as beyond control.
Insights
Vacuolated polymorphonuclear neutrophils in blood indicate severe bacterial infections and sepsis. Persistent presence of these cells for over 36 hours suggests the infection may be uncontrollable.
Area of Science:
- Hematology
- Infectious Diseases
- Microbiology
Background:
- Bacterial infections can rapidly progress to life-threatening conditions.
- Early identification of severe sepsis is critical for patient outcomes.
- Polymorphonuclear neutrophils play a key role in the immune response to bacterial pathogens.
Observation:
- Vacuolated polymorphonuclear neutrophils were observed in blood smears of patients with infections.
- The presence of these cells correlated with massive bacterial proliferation.
- Vacuolation in neutrophils appeared as a very early sign of sepsis.
Findings:
- Vacuolated polymorphonuclear neutrophils are an early indicator of severe bacterial growth.
- Their presence signifies a high risk of developing rapidly life-threatening septicemia.
- Persistence of these cells beyond 36 hours suggests disease progression beyond effective control.
Implications:
- This finding can aid in the early diagnosis and risk stratification of septic patients.
- Monitoring vacuolated neutrophils may help clinicians assess treatment efficacy.
- Further research could explore the precise mechanisms leading to neutrophil vacuolation in sepsis.