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Related Experiment Videos

Survial from acute renal failure with and without multiple organ dysfunction

G S Routh, J D Briggs, J G Mone

    Postgraduate Medical Journal
    |April 1, 1980
    PubMed
    Summary

    Hemodialysis can be worthwhile for acute renal failure patients, even with multiple organ failure. Survival rates improved over 10 years, suggesting better management techniques for kidney disease.

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    Area of Science:

    • Nephrology
    • Critical Care Medicine

    Background:

    • Acute renal failure (ARF) is a critical condition requiring renal replacement therapy.
    • The prognosis for ARF patients, particularly those with multiple organ failure (MOF), remains a significant clinical challenge.

    Purpose of the Study:

    • To evaluate the long-term survival outcomes of patients undergoing hemodialysis for ARF.
    • To assess the impact of evolving management strategies on prognosis in ARF patients, including those with MOF.

    Main Methods:

    • A 10-year retrospective analysis of 114 patients treated with hemodialysis for ARF.
    • Comparison of survival rates between patients treated in an Intensive Therapy Unit (ITU) for MOF and those treated in a Renal Unit.

    Main Results:

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  • Overall survival was 36% for ITU patients (MOF) and 63% for Renal Unit patients.
  • Survival for ITU patients improved from 31% in the first 5 years to 38% in the second 5 years, despite increasing illness severity.
  • Old age, sepsis, and gastrointestinal disease were identified as key adverse prognostic factors.

    • Conclusions:

    • Hemodialysis can be beneficial for ARF patients with MOF, challenging previous assumptions.
    • Improvements in management techniques appear to enhance survival rates in critically ill ARF patients.
    • Identifying and managing risk factors like advanced age, sepsis, and GI disease is crucial for improving outcomes.