Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acid-sensitive oesophagus

S Boesby, T Madsen, L Wallin

    Scandinavian Journal of Gastroenterology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Patients with reflux symptoms and an acid-sensitive esophagus did not differ from those with an acid-insensitive esophagus in esophageal function tests. This suggests other reflux components, not just acid, may cause symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    22q11.2 Deletion Syndrome: Cognitive, Visuomotor, and Adaptive Functioning Followed Longitudinally.

    Brain and behavior·2025
    Same author

    Child Sexual Abuse-Challenging Conditions for Adult Oral Health: A Qualitative Study.

    JDR clinical and translational research·2021
    Same author

    High suicide rates during psychiatric inpatient stay and shortly after discharge.

    Acta psychiatrica Scandinavica·2020
    Same author

    Process evaluation of a cluster randomised intervention in Swedish primary care: using care managers in collaborative care to improve care quality for patients with depression.

    BMC family practice·2019
    Same author

    Implementation of the integrated palliative care outcome scale in acute care settings - a feasibility study.

    Palliative & supportive care·2018
    Same author

    Implementation of national palliative care guidelines in Swedish acute care hospitals: A qualitative content analysis of stakeholders' perceptions.

    Health policy (Amsterdam, Netherlands)·2017
    Same journal

    Assessing trial eligibility and real-world response to vedolizumab and ustekinumab in patients with ulcerative colitis.

    Scandinavian journal of gastroenterology·2026
    Same journal

    M2 macrophage activation in recurrent acute pancreatitis: an explorative analysis of a randomized controlled trial.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Safety and performance of small bowel capsule endoscopy in patients with surgically altered gastrointestinal anatomy.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Textbook outcome after esophagectomy in Norway - a national cohort study of low- to medium-volume centers.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Fecal calprotectin concentration in adults with and without <i>Helicobacter pylori</i> infection.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled <i>ex vivo</i> study.

    Scandinavian journal of gastroenterology·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Esophageal Physiology
    • Acid Reflux Disease

    Background:

    • Gastroesophageal reflux disease (GERD) is often associated with acid reflux.
    • However, some patients with reflux symptoms have a negative acid perfusion test, indicating an acid-insensitive esophagus.
    • The role of other reflux components in symptom generation remains unclear.

    Purpose of the Study:

    • To compare esophageal function tests between patients with reflux symptoms and an acid-sensitive esophagus versus those with an acid-insensitive esophagus.
    • To investigate potential differences in manometry, acid clearing, and acid reflux.
    • To elucidate the factors contributing to reflux symptoms.

    Main Methods:

    • A comparative study involving two groups of patients with reflux symptoms.

    Related Experiment Videos

  • Group I: Acid-sensitive esophagus (positive acid perfusion test).
  • Group II: Acid-insensitive esophagus (negative acid perfusion test).
  • Esophageal function tests included manometry, acid clearing, and 12-h continuous pH monitoring.

    • Main Results:

    • No significant differences were found between the groups in gastroesophageal sphincter pressure.
    • Acid-clearing ability did not differ between the acid-sensitive and acid-insensitive esophagus groups.
    • The frequency and characteristics of acid reflux were similar in both groups, regardless of the reflux criteria used.

    Conclusions:

    • The study concludes that hydrochloric acid alone may not be the sole causative agent for symptoms in all patients with gastroesophageal reflux.
    • Other components within the reflux material likely contribute to the generation of reflux symptoms.
    • This finding has implications for understanding the pathophysiology of GERD and developing targeted therapies.