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1 alpha-hydroxyvitamin D3 in intestinal calcium malabsorption. A pilot study

E Hylander, S Jarnum

Scandinavian Journal of Gastroenterology

|January 1, 1980

Summary

Oral 1 alpha-hydroxyvitamin D3 improved calcium absorption in patients with malabsorption after small-intestinal resection. Further long-term studies are needed to compare its effects with conventional vitamin D.

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Area of Science:

Gastroenterology
Endocrinology
Nutritional Science

Background:

Small-intestinal resection or disease can lead to calcium malabsorption and steatorrhoea.
Vitamin D is crucial for calcium absorption and bone health.
1 alpha-hydroxyvitamin D3 is a vitamin D analog.

Purpose of the Study:

To evaluate the effect of oral 1 alpha-hydroxyvitamin D3 (1 alpha (OH)D3) on calcium absorption in patients with small-intestinal malabsorption.

Main Methods:

Six patients with calcium malabsorption and steatorrhoea were treated with oral 1 alpha (OH)D3 for 3 months.
Calcium absorption, bone mineral content (BMC), and urinary calcium levels were monitored.

Main Results:

A significant increase in calcium absorption was observed after 3 months of 1 alpha (OH)D3 treatment.
No significant change in bone mineral content (BMC) was noted.
Urinary calcium levels increased significantly during treatment.

Conclusions:

Oral 1 alpha-hydroxyvitamin D3 can enhance calcium absorption in patients with small-intestinal malabsorption.
Long-term comparative studies are necessary to assess the efficacy and safety of 1 alpha (OH)D3 versus conventional vitamin D.

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