Related Experiment Videos
The in vitro effect of neurotensin on human jejunal mast cells
Neurotensin was added to human jejunal mucosal biopsy specimens from six individuals. Fifty-seven per cent degranulation of mast cells was seen at a concentration of neurotensin of 10(-9) M and 43% at 10(-6) M, as compared with 31% with IgE antibody/antigen. There was no change in degranulation with neurotensin when IgE was added to biopsy specimens before neurotensin in a 10(-6) M solution. This effect of neurotensin on human jejunal mast cells supports the evidence for receptors for neurotensin on mast cells shown in rat experiments.
Neurotensin was added to human jejunal mucosal biopsy specimens from six individuals. Fifty-seven per cent degranulation of mast cells was seen at a concentration of neurotensin of 10(-9) M and 43% at 10(-6) M, as compared with 31% with IgE antibody/antigen. There was no change in degranulation with neurotensin when IgE was added to biopsy specimens before neurotensin in a 10(-6) M solution. This effect of neurotensin on human jejunal mast cells supports the evidence for receptors for neurotensin on mast cells shown in rat experiments.