[Evaluation of pertussis vaccine toxicity by the paw edema test in mice]

Experiments on randombred mice were made to find out the prospects of using the paw edema test to determine the toxicity characteristics of pertussis vaccines. In experiments with preparations of known toxicity, determined on the basis of LTD50 and the dynamics of the body weight of the animals, the results of the commonly accepted tests correlated well with the results of the paw edema test in mice. The paw edema test allowed to reveal the presence of "residual" toxicity in microbial suspension presented a "nontoxic" pertussis vaccine.