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Morphological changes in spontaneously hypertensive rats

S Nag, D M Robertson, H B Dinsdale

    Acta Neuropathologica
    |January 1, 1980
    PubMed
    Summary
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    Spontaneously hypertensive rats exhibit increased cerebrovascular permeability, primarily due to enhanced pinocytosis. These early changes in blood vessels precede medial hyperplasia and fibrin deposition.

    Area of Science:

    • Neuroscience
    • Cardiovascular Science
    • Pathology

    Background:

    • Previous research linked angiotensin-induced hypertension to increased intracerebral arteriolar permeability and pinocytosis.
    • Spontaneous hypertension models offer insights into non-pharmacologically induced chronic hypertensive conditions.

    Purpose of the Study:

    • To investigate cerebrovascular permeability and associated mechanisms in spontaneously hypertensive rats (SHR) over an 82-week period.
    • To determine if enhanced pinocytosis is a key factor in early cerebrovascular alterations in chronic hypertension.

    Main Methods:

    • Cerebrovascular permeability was assessed using horseradish peroxidase (HRP) in SHR.
    • Microscopic examination (light microscopy) evaluated vessel morphology, including medial hyperplasia and fibrin deposition.

    Related Experiment Videos

  • Quantitative analysis focused on pinocytotic vesicle counts in arteriolar segments.

    • Main Results:

    • Increased cerebrovascular permeability to HRP was observed in some SHR, correlating with enhanced pinocytosis.
    • A significant increase in pinocytotic vesicles was noted in permeable arteriolar segments, indicating pinocytosis as a principal mechanism.
    • Medial hyperplasia was evident in renal vessels by 16 weeks and later in ocular and cerebral vessels.
    • Fibrin deposition in renal vessels occurred from 64 weeks but did not lead to renal failure.

    Conclusions:

    • Enhanced pinocytosis is a primary mechanism contributing to early cerebrovascular changes in spontaneously hypertensive rats.
    • Spontaneous hypertension involves progressive vascular remodeling, including medial hyperplasia and fibrin deposition, with varying timelines across different organ systems.