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Serum chloride--a CAP survey

K R Geisinger, K F Geisinger, P E Wakely

    American Journal of Clinical Pathology
    |October 1, 1980
    PubMed
    Summary
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    Laboratory measurements of serum chloride levels in the 1978 CAP Chemistry Survey showed that automated colorimetric methods were most common. All techniques yielded clinically comparable results, with ion-selective electrodes offering the best precision.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Analytical Chemistry

    Background:

    • The College of American Pathologists (CAP) Chemistry Survey is a key program for assessing laboratory performance.
    • Serum chloride measurement is a vital diagnostic test in clinical practice.
    • Evaluating laboratory methods used in proficiency testing is crucial for quality assurance.

    Purpose of the Study:

    • To evaluate the laboratory measurement methods for serum chlorides used in the 1978 CAP Chemistry Survey.
    • To identify the most prevalent methods and assess their performance characteristics.

    Main Methods:

    • Analysis of data from the 1978 CAP Chemistry Survey.
    • Categorization of reported laboratory methods for serum chloride determination.
    • Comparison of interlaboratory precision across different analytical techniques.

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    Main Results:

    • Automated colorimetric systems were the most frequently utilized method for serum chloride measurement.
    • Electrometric, mercurimetric, and ion-selective methods were also employed.
    • All evaluated methods produced clinically comparable data for serum chloride levels.
    • Ion-selective electrode methods demonstrated the highest interlaboratory precision.
    • Mercurimetric methods exhibited the widest variation in interlaboratory results.

    Conclusions:

    • The 1978 CAP Chemistry Survey indicated a reliance on automated colorimetric methods for serum chloride analysis.
    • Despite variations in precision, all common methods provided clinically acceptable results.
    • Ion-selective electrodes represent a precise method for serum chloride determination in laboratory settings.