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Polymicrobial sepsis: an analysis of 184 cases using log linear models

P A Mackowiak, R H Browne, P M Southern

    The American Journal of the Medical Sciences
    |September 1, 1980
    PubMed
    Summary

    Polymicrobial sepsis, a serious condition, is linked to underlying diseases, lack of fever, lung infections, low blood pressure, and hospital-acquired infections. Treatment effectiveness remains unclear.

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    Area of Science:

    • Infectious Diseases
    • Clinical Medicine
    • Epidemiology

    Background:

    • Polymicrobial sepsis is a prevalent and often fatal condition.
    • Limited research has focused on this specific clinical entity.

    Purpose of the Study:

    • To retrospectively analyze clinical data of polymicrobial sepsis patients.
    • To identify factors correlated with mortality in polymicrobial sepsis.

    Main Methods:

    • Review of 184 patient case records from 1972-1977.
    • Utilized log-linear models for statistical analysis of clinical data.

    Main Results:

    • Mortality correlated positively with underlying disease, absence of fever, pulmonary source, hypotension, and hospital-associated sepsis.

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  • No significant correlation found with age, hospital service, microbial species, microbial load, WBC count, or antimicrobial therapy.

    • Conclusions:

    • Identified key clinical factors associated with increased polymicrobial sepsis mortality.
    • The necessity of broad-spectrum antimicrobial therapy against all causative agents requires further investigation.