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Permeability into aortic intima and atherosclerotic plaque
Angiology
|August 1, 1980
Summary
Plasma constituent permeability in the aorta changes with age and atherosclerosis. Dye perfusion revealed decreased thoracic aorta permeability and distinct abdominal aorta patterns, with bilirubin and fibrin deposition correlating to permeability.
Area of Science:
- Cardiovascular Biology
- Vascular Physiology
- Atherosclerosis Research
Background:
- Atherosclerosis involves changes in aortic wall permeability.
- Understanding plasma constituent transport is crucial for atherosclerosis research.
Purpose of the Study:
- To investigate the relationship between plasma constituent permeability and atherosclerosis.
- To analyze age-related changes in aortic permeability.
- To examine permeability in atherosclerotic plaques and surrounding regions.
Main Methods:
- Human aorta perfusion with dye solution.
- Quantification of permeability depth relative to intima thickness.
- Investigation of bilirubin and fibrin deposition in plaques.
Main Results:
- Thoracic aorta permeability ratio decreased with age.
- Abdominal aorta permeability showed high values in young adults, decreasing with age.
- Permeability into atheromatous plaques was diffuse in young adults, becoming shallower with age.
- Greatest permeability observed on the lower side of plaques.
- Bilirubin and fibrin deposition patterns mirrored permeability.
Conclusions:
- Aortic permeability is influenced by age and the presence of atherosclerosis.
- Regional differences in permeability exist around atherosclerotic plaques.
- Plasma constituent deposition, including bilirubin and fibrin, correlates with permeability patterns in atherosclerosis.