Trimethoprim and sulfadiazine: experimental infection of Beagles

The purpose in the present study was to determine whether the commercial combination of trimethoprim (TMP) and sulfadiazine (SDZ) tribrissen (TRI) was more effective than either of the components for treating experimentally induced infection of Streptococcus zooepidemicus. Two dose levels of each were given subcutaneously for treatment, and their effectiveness was compared with that of sulfadimethoxine (SDM) in terms of (i) clinical manifestations, (ii) hematologic changes, (iii) blood culture examinations, and (iv) tissue culture examinations. According to these four measurements, the combination TMP/SDZ was more effective than either of the components. This effect was observed at the two dosages of TRI (30 and 15 mg/kg). The higher dosage, however, was more effective as demonstrated by three of the measurements. Alone, TMP and SDZ were not effective, but SDM treatment was effective in this model.