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[Diagnostic value of C reactive protein in neonatal sepsis (author's transl)]
Insights
C-reactive protein (CRP) is a highly sensitive marker for diagnosing sepsis in newborns. Elevated CRP levels accurately identified sepsis in 100% of confirmed cases, outperforming other blood tests.
Area of Science:
- Pediatrics
- Clinical Chemistry
- Infectious Diseases
Context:
- Neonatal infections pose a significant health risk.
- Early and accurate diagnosis of sepsis is critical for effective treatment.
- Traditional diagnostic methods may have limitations in sensitivity.
Purpose:
- To evaluate the diagnostic utility of serum C-reactive protein (CRP) levels in identifying sepsis in infants under one month old.
- To compare the sensitivity of CRP with other hematological parameters in neonatal sepsis diagnosis.
Summary:
- This study measured serum C-reactive protein (CRP) levels in 125 infants under one month, including 75 healthy controls and 50 suspected of infection.
- Bacteriological studies and white blood cell differential counts were also performed.
- High CRP concentrations were detected in 100% of infants with bacteriologically confirmed sepsis, while levels remained unchanged in healthy infants and those without confirmed sepsis.
Impact:
- Serum CRP demonstrates significantly higher sensitivity than other hematological indices for diagnosing neonatal sepsis.
- CRP measurement can aid in the rapid and accurate identification of sepsis in newborns.
- This finding supports the integration of CRP testing into routine neonatal sepsis screening protocols.
Abstract:
Seric levels of C reactive protein (C.R.P.) were determined in a series of 125 children under one month old. Of them, 75 were clinically healthy and 50 showed signs that suggested infection. In all this infants, in addition to C.R.P., different components of white blood cell differential count were determined, and a bacteriological study was undergone. Authors found high concentration of C.R.P. in 100% of children in which diagnosis of sepsis was bacteriologically confirmed. On the other hand, concentrations of this biological parameter were not substantially modified in newborns used in the control, nor in those other ones in which sepsis was not confirmed. Sensibility of C.R.P. showed itself significantly higher than other hematological indexes in study.