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Published on: July 22, 2011
Regional enteritis: evidence for genetic transmission by HLA typing
Annals of Internal Medicine
|September 1, 1980
Summary
Genetic factors may influence regional enteritis. This study found a strong association between human leukocyte antigen (HLA) identity in affected siblings, suggesting a genetic link to the disease.
Area of Science:
- Immunogenetics
- Gastroenterology
- Human Genetics
Background:
- Regional enteritis, also known as Crohn's disease, has a complex etiology with suspected genetic and environmental factors.
- Previous studies have explored associations between various genetic markers and regional enteritis, but definitive links remain elusive.
Purpose of the Study:
- To investigate the association between human leukocyte antigen (HLA) -A and -B loci and the development of regional enteritis.
- To compare HLA antigen frequencies in familial and nonfamilial cases of regional enteritis with a healthy control population.
Main Methods:
- Lymphocyte typing was performed on sibling pairs affected with regional enteritis.
- HLA antigen and haplotype frequencies were analyzed in familial cases, nonfamilial cases (n=22), and normal blood donors (n=402).
Main Results:
- No specific HLA haplotype was identified in more than one kindred.
- No significant difference in HLA antigen prevalence was observed between nonfamilial regional enteritis patients and the normal population.
- A high frequency of HLA identity (sharing both haplotypes) was found in affected sibling pairs (4 out of 5 pairs).
Conclusions:
- The strong HLA identity among affected siblings suggests a significant genetic linkage between the histocompatibility locus and regional enteritis.
- A genetic component is likely involved in the pathogenesis of regional enteritis, particularly within affected families.
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