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Corticosteroid-responsive hypercalcemia with elevated serum 1-alpha, 25 dihydroxyvitamin D

B Frame, A M Parfitt

Annals of Internal Medicine

|September 1, 1980

Summary

This study details a patient with persistent hypercalcemia and hypercalciuria, unresponsive to common treatments but responsive to corticosteroids. The findings suggest a unique calcium metabolism disorder potentially mimicking sarcoidosis.

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Area of Science:

Endocrinology
Nephrology
Calcium Metabolism Disorders

Background:

Presents a long-standing case of absorptive hypercalciuria and hypercalcemia in a 51-year-old male.
Highlights the absence of typical causes like primary hyperparathyroidism or hypervitaminosis D.

Observation:

The patient exhibited elevated serum calcium and 1 alpha, 25(OH)2D levels.
These levels normalized with corticosteroid treatment, indicating a corticosteroid-responsive condition.

Findings:

The patient's calcium metabolic disturbance mimicked sarcoidosis.
Despite characteristic symptoms, extensive investigations ruled out sarcoidosis.

Implications:

Suggests the existence of rare, corticosteroid-responsive hypercalcemia and hypercalciuria syndromes.
Underscores the importance of considering atypical calcium disorders when common causes are excluded.