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Corticosteroid-responsive hypercalcemia with elevated serum 1-alpha, 25 dihydroxyvitamin D

B Frame, A M Parfitt

    Annals of Internal Medicine
    |September 1, 1980
    PubMed

    Insights

    This study details a patient with persistent hypercalcemia and hypercalciuria, unresponsive to common treatments but responsive to corticosteroids. The findings suggest a unique calcium metabolism disorder potentially mimicking sarcoidosis.

    Area of Science:

    • Endocrinology
    • Nephrology
    • Calcium Metabolism Disorders

    Background:

    • Presents a long-standing case of absorptive hypercalciuria and hypercalcemia in a 51-year-old male.
    • Highlights the absence of typical causes like primary hyperparathyroidism or hypervitaminosis D.

    Observation:

    • The patient exhibited elevated serum calcium and 1 alpha, 25(OH)2D levels.
    • These levels normalized with corticosteroid treatment, indicating a corticosteroid-responsive condition.

    Findings:

    • The patient's calcium metabolic disturbance mimicked sarcoidosis.
    • Despite characteristic symptoms, extensive investigations ruled out sarcoidosis.

    Implications:

    • Suggests the existence of rare, corticosteroid-responsive hypercalcemia and hypercalciuria syndromes.
    • Underscores the importance of considering atypical calcium disorders when common causes are excluded.

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