Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pancreatic necrosis in progressive systemic sclerosis

A A Abraham, A Joos

Annals of the Rheumatic Diseases

|August 1, 1980

Summary

Progressive systemic sclerosis can cause fatal pancreatic necrosis due to acute arteritis. This case highlights active vascular lesions in the kidneys and pancreas, leading to severe outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nightmares and insomnia are frequent in patients with functional neurological disorders.

Journal of psychosomatic research·2025

Same author

Qualitative research on the acceptance of evolving evidence for HTA body approval of innovative health technologies in selected European countries.

Expert review of pharmacoeconomics & outcomes research·2025

Same author

Patient-reported outcome measures obtained via E-Health tools ease the assessment burden and encourage patient participation in cancer care (PaCC Study).

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2021

Same author

[Functional neurological disorders: update and example of integrated inpatient treatment including mirror therapy].

Der Nervenarzt·2019

Same author

Integrated inpatient rehabilitation for patients with Functional Neurological Symptom Disorder (FNSD) - A specific group therapy.

Journal of psychosomatic research·2019

Same author

Clinical Trial Results Summary for Laypersons: A User Testing Study.

Therapeutic innovation & regulatory science·2018

Area of Science:

Pathology
Nephrology
Gastroenterology

Background:

Progressive systemic sclerosis (PSS), a multisystem autoimmune disease, is characterized by fibrosis and vascular abnormalities.
Renal and pancreatic complications are known but often underdiagnosed manifestations of PSS.
Arteritis, inflammation of arteries, can affect various organs in PSS, leading to ischemia and necrosis.

Observation:

A patient with PSS presented with severe hypertension and renal involvement, confirmed by biopsy showing active vascular lesions.
Autopsy revealed inactive renal lesions with characteristic concentric fibrosis.
The pancreas exhibited significant vascular pathology, with both chronic proliferative and acute arteritic changes.

Findings:

Fatal pancreatic necrosis was directly attributed to extensive acute arteritic changes in the pancreatic vasculature.
The disparity between active vascular lesions in the initial presentation and the inactive renal lesions at autopsy suggests disease progression and organ-specific vascular involvement.
The pancreatic vascular lesions demonstrated a mixed pattern of chronic and acute inflammation.

Implications:

This case underscores the critical role of vascular involvement in the pathogenesis of PSS complications.
Early recognition and management of arteritis in PSS may be crucial for preventing severe organ damage, including pancreatic necrosis.
Further research into the specific mechanisms of pancreatic vascular damage in PSS is warranted.

Related Experiment Videos