Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Oxacillin nephritis

D B Tillman, P A Oill, L B Guze

Archives of Internal Medicine

|November 1, 1980

Summary

This summary is machine-generated.

Oxacillin can cause acute interstitial nephritis, a kidney condition, in patients. This antibiotic-associated kidney injury is reversible upon drug discontinuation, highlighting a new penicillin-induced adverse effect.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: estimates of receptor depth and threshold.

The Journal of physiology·1995

Same author

Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain threshold in humans.

The Journal of physiology·1995

Same author

Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli.

Journal of neurophysiology·1991

Same author

Experimental Escherichia coli endocarditis in rats: roles of serum bactericidal activity and duration of catheter placement.

Infection and immunity·1988

Same author

Strain-dependent difference in susceptibility of mice to experimental ascending pyelonephritis.

The Journal of infectious diseases·1987

Same author

Strain-dependent differences in susceptibility of mice to experimental pyelonephritis.

The Journal of infectious diseases·1985

Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017

Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017

Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017

Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017

Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017

Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013

See all related articles

Area of Science:

Nephrology
Pharmacology
Internal Medicine

Background:

Acute interstitial nephritis (AIN) is a known adverse effect of various antibiotics.
Penicillins are frequently implicated in drug-induced AIN.
Oxacillin, a penicillinase-resistant penicillin, has not been previously reported as a cause of AIN.

Observation:

An 80-year-old male patient presented with a progressive increase in serum creatinine levels.
The patient was receiving oxacillin sodium for a presumed infection.
Laboratory investigations revealed eosinophiluria, a potential marker for drug-induced hypersensitivity.

Findings:

Discontinuation of oxacillin sodium led to a significant improvement in renal function, with creatinine levels returning to baseline.

Related Experiment Videos

The resolution of renal dysfunction and eosinophiluria upon drug withdrawal strongly suggests oxacillin as the causative agent.

This case report provides the first direct evidence linking oxacillin to the development of acute interstitial nephritis.

Implications:

Oxacillin should be considered a potential cause of antibiotic-associated acute interstitial nephritis.
Clinicians should maintain a high index of suspicion for oxacillin-induced AIN in patients presenting with unexplained renal dysfunction and eosinophiluria.
This finding expands the spectrum of penicillin-related nephrotoxicity and necessitates careful medication review in patients with AIN.