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Related Experiment Videos

Aging of the optic nerve

C L Dolman, A Q McCormick, S M Drance

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Optic nerve aging involves axon loss and structural changes, potentially reducing vision in older adults. Degenerative changes suggest age-related vascular impairment impacts optic nerve health.

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    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Gerontology

    Background:

    • The optic nerve undergoes significant development and changes throughout the human lifespan.
    • Understanding age-related alterations is crucial for diagnosing and managing visual impairments.

    Purpose of the Study:

    • To investigate the histologic changes in the human optic nerve from birth to old age.
    • To correlate structural changes with potential functional consequences and underlying pathologies.

    Main Methods:

    • Histologic examination of 300 human optic nerves.
    • Analysis of age-related structural modifications, including myelination, connective tissue growth, and cellular changes.

    Main Results:

    • The optic nerve is unmyelinated at birth, rapidly myelinates, and shows increasing connective tissue with age.

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  • Axon count diminishes with age, likely due to ganglion cell loss, contributing to reduced visual acuity.
  • Age-associated changes include corpora amylacea, lipofuscin accumulation, axonal swelling, and Schnabel's degeneration, indicative of vascular issues.

    • Conclusions:

    • Optic nerve aging is characterized by progressive axon loss and structural remodeling.
    • Age-related vascular impairment is common in the elderly, manifesting as degenerative changes in the optic nerve.
    • These findings highlight the structural basis for age-related visual decline.