Hearing loss from hemodialysis

A 47-year-old man with normal hearing had chronic progressive renal failure. He experienced hearing loss in additive increments with peritoneal dialysis and hemodialysis, until he was profoundly deaf in both ears. Postmortem studies showed collapse of the endolymphatic system and edema and atrophy of most of the specialized cell types of the auditory and vestibular sense organs. It is our interpretation that the alterations were caused by osmotic disequilibrium associated with hemodialysis.