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Related Experiment Videos

Cambendazole toxicity in calves

D C Main, D E Vass

    Australian Veterinary Journal
    |May 1, 1980
    PubMed
    Summary

    Cambendazole, a dewormer, caused fatal toxicity in three dairy calves at a high dose of 98.5 mg/kg. The toxic effects included severe lung and lymphatic system damage.

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    Area of Science:

    • Veterinary Toxicology
    • Animal Pathology

    Background:

    • Cambendazole is an anthelmintic commonly used in livestock.
    • High-dose toxicity studies are crucial for establishing safe usage limits.

    Purpose of the Study:

    • To investigate the toxic effects of a high dose of cambendazole in dairy calves.
    • To document the pathological findings associated with cambendazole-induced mortality.

    Main Methods:

    • Administration of 98.5 mg/kg cambendazole to 8 dairy calves.
    • Clinical observation and post-mortem examination of affected animals.

    Main Results:

    • Three out of eight dairy calves died following cambendazole administration.
    • Significant pathological findings included marked pleural effusion, severe pulmonary edema, and necrotic lymphadenopathy.

    Conclusions:

    • A high dose of cambendazole (98.5 mg/kg) is associated with severe toxicity and mortality in dairy calves.
    • The observed lesions indicate significant damage to the pulmonary and lymphatic systems.

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